Most of the time, cant and lift is used to get a more natural stance. And like mentionned previously, it is usually oriented towrds the center of the board. Also, with canting and lifting, you can get a wider stance, giving more stability and power, but it depends on your liking. Lots of people here like 3 front and 3 rear, I personnaly ride 0 front and rear.
In your case, your burning thigh may be due to the fact that you're putting too much pressure on it. There are several factors coming into consideration. With the exact same setup, I had burning in the FRONT thigh because the rear canting was pushing my weight forward, so I'm not really sure what to do here...
Derf